Mentifex mentifex at scn.org
Mon Sep 21 14:26:03 EST 1998

Richard M Wagers <cortical at earthlink.net> [Is that an ex-officio e-mail?]
of Organization: Synapse [ Is that the journal "Synapse"? ] kindly wrote:

Yves De Rop:
>>>Does someone knows what an ephapse is?
> First, let me say I'm impressed with [the] answer from "Mentifex".
> He has quite an understanding of language.  However, maybe I can
> provide an explanation/example to help clarify his illuminating
> description.
> This term is occasionally used to explain how sympathetically maintained
> pain (RSDS) may develop.  It is presumed that when the regenerating
> sprouts of sympathetic efferent and nociceptive primary afferents (both
> are non-myelinated C-type fibers) come in close proximity they form an
>"artificial synapse" called an Ephapse.  The term isn't used commonly in
> the literature.  Below are two references which (although old) may
> better clarify this topic.  Hope this is helpful.
> Richard-

> Granit R, Skoglund DR:  Facilitation, inhibition and depression at the
>"artifical synapse" formed by the cut end of   a mammalian nerve.  J
> Physiology 103:435-448, 1945.
> Doupe J, Cullen CH, Chance GQ:  Post-traumatic pain and the causalgic
> syndrome.  J Neurol Neurosurg Psychiatry 7:33-48, 1944

  From where I (Mentifex/Arthur) sit on the U.S. West Coast, we have seen
  Robert Stonehouse relate "Ephapse" to astronomy; then
  Nikos Sarantakos gave us the authentically Hellenic viewpoint; next
  Kalman Rubinson started the technical explanation, which
  Richard M. Wagers has wrapped up with literature references.

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