Presupplementary Motor Area Activation (TYPO)

F. Frank LeFever flefever at
Mon Aug 2 23:02:41 EST 1999

Meant to write, of course, "COMPLETING the learning of a task"!

F. LeFever

In <7o36ie$ktp at> flefever at
Frank LeFever) writes: 
>In <933430839.761743 at> "John"
><johnhkm at> writes: 
>>"The pre-SMA activation remained unchanged during learning of
>>associations but decreased during learning of sequences, suggesting
>that the
>>pre-SMA is related to visuo-motor association rather than sequence"
>Haven't read it, but I'll offer the following:
>DECREASING activation has in some other contexts been related to
>competing the learning of a task, I believe.
>A patient of mine had some visual-associative prooblems which I
>suggested might be due to problems with posterior circultation (I had
>become much interested in transient vertebrobasilar insufficiency as
>well as infarcts in various distal reaches of their distribution,
>myu first experience with a locked-in patient).  She also had enormous
>difficulties with a sequencing task (actually an altrenating sequence
>borrowed from Luria).
>The attending (a neurologist) was scathing--"Vertebrobasilar lesions
>are SO overdiagnosed!!"  However, after he, a visiting neurologist,
>one or two neurology residents couldn't decide whether they had
>elicited a Babinski reflex, they ordered a CT, looking for enlarged
>ventricles--i.e., normopressure hydrocephaly--to explain her
>(which I knew from my neuropsychological testing she definitely did
>  CT showed bilateral infarcts in (1) visual cortex or nearby
>(verifying my suspicion about posterior circulation), and (2)
>dorso-medial frontal cortex (i.e. SMA).
>This lovely and definitely non-demented elderly lady was not dismayed
>to learn she had a non-treatable condition, but was grateful to learn
>that she did not have possibly hereditary dementing disorder to pass
>to her grandchildren...
>F. Frank LeFever, Ph.D.
>New York Neuropsychology Group

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