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Organophosphate Induced Polyneuropathy and Parkinson's

Tim Tillman tillman at ithink.net
Thu Feb 11 01:46:36 EST 1999


Nancy,

You can try the following:

TITLE:  Single case study. Possible organophosphate-induced parkinsonism.
AUTHORS:  Davis KL; Yesavage JA; Berger PA
SOURCE:  J Nerv Ment Dis 1978 Mar;166(3):222-5
CITATION IDS:  PMID: 641541 UI: 78152828
ABSTRACT:  A case of possible organophosphate-induced parkinsonism is
presented. The patient was a crop duster with numerous episodes of acute
organophosphate intoxication and chronic organophosphate exposure. The
etiology of parkinsonism is discussed in terms of a balance hypothesis
between cholinergic and dopaminergic neurotransmission in the striatum. A
possible relationship between chronic organophosphate exposure and
alterations in central cholinergic or dopaminergic activity is suggested.
The course of this patient raises the possibility that agricultural workers
may be at risk for the late development of parkinsonism.
MAIN MESH HEADINGS:  Insecticides, Organophosphate/*adverse effects
Parkinson Disease, Symptomatic/*chemically induced
ADDITIONAL MESH HEADINGS:  Case Report
Human
Male
Middle Age
Parkinson Disease, Symptomatic/drug therapy
Psychoses, Substance-Induced/etiology
Trihexyphenidyl/adverse effects
Trihexyphenidyl/therapeutic use
PUBLICATION TYPES:  JOURNAL ARTICLE
LANGUAGES:  Eng


TITLE: Drug induced parkinsonism [letter]
AUTHORS: Wilson JA; Primrose WR
SOURCE: Br Med J (Clin Res Ed) 1986 Oct 11;293(6552):957
CITATION IDS: PMID: 3094735 UI: 87027335
MAIN MESH HEADINGS: Parkinson Disease, Symptomatic/*chemically induced
ADDITIONAL MESH HEADINGS: Human
Risk
PUBLICATION TYPES: LETTER
LANGUAGES: Eng


TITLE: Organophosphate poisoning in office workers.
AUTHORS: Hodgson MJ; Block GD; Parkinson DK
SOURCE: J Occup Med 1986 Jun;28(6):434-7
CITATION IDS: PMID: 2425064 UI: 86253427
ABSTRACT: Five occupants of an office developed symptoms compatible with
organophosphate intoxication after application of chlorpyrifos, a moderately
toxic pesticide. Recovery of erythrocyte cholinesterase levels occurred
during the subsequent three months but followed an exponential distribution
rather than the constant rate of recovery most investigators have assumed.
This pattern suggests redistribution of the active organophosphate after
absorption to a second body compartment with subsequent slow release of the
still active substance into the bloodstream.
MAIN MESH HEADINGS: Chlorpyrifos/*poisoning
Insecticides, Organophosphate/*poisoning
Occupational Diseases/*chemically induced
Poisoning/*etiology
ADDITIONAL MESH HEADINGS: Adult
Cholinesterases/blood
Disease Outbreaks
Erythrocytes/enzymology
Female
Human
Male
Mathematics
United States
PUBLICATION TYPES: JOURNAL ARTICLE
CAS REGISTRY NUMBERS: EC 3.1.1.8 (Cholinesterases)
0 (Insecticides, Organophosphate)
2921-88-2 (Chlorpyrifos)
LANGUAGES: Eng



TITLE: Diagnosis of organophosphate intoxication [letter]
AUTHORS: Hodgson MJ; Parkinson DK
SOURCE: N Engl J Med 1985 Aug 1;313(5):329
CITATION IDS: PMID: 2409442 UI: 85240484
MAIN MESH HEADINGS: Insecticides, Organophosphate/*poisoning
ADDITIONAL MESH HEADINGS: Carbamates/poisoning
Case Report
Chlorpyrifos/poisoning
Environmental Exposure
Human
PUBLICATION TYPES: LETTER
CAS REGISTRY NUMBERS: 0 (Carbamates)
0 (Insecticides, Organophosphate)
2921-88-2 (Chlorpyrifos)
6414-57-9 (N-methylcarbamate)
LANGUAGES: Eng





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