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LTP vs LTD

Richard Vickery Richard.Vickery at unsw.edu.au
Mon Feb 22 19:54:51 EST 1999


Wookie wrote:

> LTP [long term potentiation] which increases synaptic strength (larger
> EPSC's which leads to larger EPSP's)
> and LTD [Long Term Depression] that decreases synaptic strength.

> In LTP the post-synaptic [Ca2+] rises very high (up to 5 micromolar)
> in LTD the post-synaptic [Ca2+] rises only slightly [lower than 1
> micromolar].
> So there you have it, these differences in concentration determine
> what enzymes are used.

> How can this difference in concentration alone account for the choice
> of enzymes?

Check out 
J. Lisman 1989
PNAS 86: 9574-9578
A mechanism for the Hebb and anti-Hebb processes underlying
learning and memory.

You could do a citation search forward from there if you need to.

-- 
Dr Richard Vickery                  
School of Physiology & Pharmacology, UNSW, Australia, 2052
ph. 61 2 93851676,  fax 61 2 93851059              
http://www.med.unsw.edu.au/Physiology/School/staff/vickery/Welcome.html



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