> LTP [long term potentiation] which increases synaptic strength (larger
> EPSC's which leads to larger EPSP's)
> and LTD [Long Term Depression] that decreases synaptic strength.
> In LTP the post-synaptic [Ca2+] rises very high (up to 5 micromolar)
> in LTD the post-synaptic [Ca2+] rises only slightly [lower than 1
> So there you have it, these differences in concentration determine
> what enzymes are used.
> How can this difference in concentration alone account for the choice
> of enzymes?
J. Lisman 1989
PNAS 86: 9574-9578
A mechanism for the Hebb and anti-Hebb processes underlying
learning and memory.
You could do a citation search forward from there if you need to.
Dr Richard Vickery
School of Physiology & Pharmacology, UNSW, Australia, 2052
ph. 61 2 93851676, fax 61 2 93851059