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LTP vs LTD

AFJ van Aken koetje at boe.nl
Wed Feb 24 05:57:59 EST 1999


On Tue, 23 Feb 1999 18:06:40 -0800, "Austin P. So (Hae-Jin)"
<haejin at netinfo.ubc.caX> wrote:

>I'd suggest these papers:
>
>De Koninck P, Schulman H.Science 1998 Jan 9;279(5348):227-30
>Dolmetsch RE, Xu K, Lewis RS. Nature 1998 Apr 30;392(6679):933-6
>Bhalla and Iyengar Science 1999 Jan 15; 283 381-387.
>
>It isn't so much the difference in concentration as it is the oscillation
>frequency of [Ca2+] fluctuations...and we are also talking about
>populations of proteins at various activation states...so it's really a
>game of tag.
>
>Besides I wouldn't put too much faith in the LTP/LTD models, but that's
>just my humble opinion...

And why is that?
I've been reading about LTP processes in which no NMDA receptors are
being used.
Would you suggest that LTP models are an overgeneralization?

greetings

AFJ van Aken




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