I'd suggest these papers:
De Koninck P, Schulman H.Science 1998 Jan 9;279(5348):227-30
Dolmetsch RE, Xu K, Lewis RS. Nature 1998 Apr 30;392(6679):933-6
Bhalla and Iyengar Science 1999 Jan 15; 283 381-387.
It isn't so much the difference in concentration as it is the oscillation
frequency of [Ca2+] fluctuations...and we are also talking about
populations of proteins at various activation states...so it's really a
game of tag.
Besides I wouldn't put too much faith in the LTP/LTD models, but that's
just my humble opinion...
> So there you have it, these differences in concentration determine
> what enzymes are used.
> In LTP (with high concentrations Ca2+) Protein kinases are activated
> while in
> LTD (with low concentrations Ca2+) Protein phosphatases are activated.
> I'm lost here , how can this be?
> How can this difference in concentration alone account for the choice
> of enzymes?
> My guess is that there is some time dependence too.
> In LTP there is a huge Calciumflux in a short period
> whle in LTD there are small calcium fluxes in shorter periods.
> Who knows more about the relation between Ca2+ concentration and
> the activiation of kinases/phosphatases?
Austin P. So (Hae Jin)
University of British Columbia
E-mail: haejin at netinfo.ubc.ca