# Neurotoxicity assays?

Eugene Leitl eugene.leitl at lrz.uni-muenchen.de
Mon Jul 19 17:24:41 EST 1999

Why not using C. elegans, and simply assay for motility? Easy as \pi.

Richard Norman writes:
> There has got to be SOMEthing you can do with those enormous
> slugs in that area!   Unfortunately, I am not familiar with "nerve
> fasicle" assay.  Do you mean, simply, nerve bundles?  As in
> compound action potential?  The fact is, most neurotoxins act
> synaptically rather than on the axon, so you would need some CNS
> (or neuromuscular junction) involvement.
>
> I believe there is a volume in the series "Methods in Neurosciences"
> by Academic Press dealing with toxicology that you should investigate.
>
> Who are the likely targets for the toxin?  They would be your best bet
> for an assay.
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