LTP and learning
KPaulC at email.msn.com
Tue Jul 27 00:03:35 EST 1999
the press release didn't provide sufficient info, but simply inducing and
'LTP'-like condition indiscriminantly with respect to the
topologically-distributed nature of 'normal' nervous system function, does
not eliminate all of the trophic consequences inherent in the
non-interfered-with resultant activation 'state', and if there's enough
information remaining in the resultant activation 'state' to allow the TD
E/I-minimization mechanisms to achieve convergence upon a supersystem
configuration, the nervous system ('brain') does exactly that, and an
'appropriate' behavioral response is 'addressed' via the TD E/I-minimization
with respect to what's left, 'after' the experimental stuff is 'applied'.
within the tightly-integrated neural topology, the forced,
indiscriminant-of-the-TD, 'LTP'-like condition, in fact, constitutes a
relatively-random activation sub-'state'... a TD E/I(up) sub-'state'... and
any remaining (non-interfered-with) TD E/I-minimization mechanisms just
'whittle' (AoK, Ap5) it away, as they 'normally' do with with other
superfluous (relatively-random) activation.
it's been a major shortcoming of most experiments in Neuroscience that the
tight mapping of the neural topology has been largely ignored... if an
experimental design is not engineered in a way that keeps the Topology of
the experimental part commensurate with the innate neural Topology, then, to
the degree of such, the experiment yields False results.
K. P. Collins
John wrote in message <933043969.298961 at server.australia.net.au>...
>"There still remains, however, one unresolved and very controversial issue:
>To what extent does long-term potentiation participate in learning and
>memory acquisition? Contrary to their expectations, the scientists from
>Heidelberg could not demonstrate abnormal learning behaviour in the mutant
>mice. Rather, the mice lacking LTP were, like normal mice, capable of
>accurately finding a submerged, invisible platform in a pool of murky water
>("water maze") and to swim there immediately when placed in the water."
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