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neurobiology of autism

Marcello Spinella marshmallow at earthlink.net
Sat Mar 27 10:11:17 EST 1999

This might be of interest:

J Assoc Acad Minor Phys 1998;9(1):9-15 

Improved social and language skills after secretin administration in
patients with autistic spectrum disorders.

Horvath K, Stefanatos G, Sokolski KN, Wachtel R, Nabors L, Tildon JT

We report three children with autistic spectrum disorders who underwent
upper gastrointestinal endoscopy and intravenous administration of
secretin to stimulate pancreaticobiliary secretion. All three had an
increased pancreaticobiliary secretory response when compared with
nonautistic patients (7.5 to 10 mL/min versus 1 to 2 mL/min). Within 5
weeks of the secretin infusion, a significant amelioration of the
children's gastrointestinal symptoms was observed, as was a dramatic
improvement in their behavior, manifested by improved eye contact,
alertness, and expansion of expressive language. These clinical
observations suggest an association between gastrointestinal and brain
function in patients with autistic behavior. 

PMID: 9585670, UI: 98246761

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