Gamma-OH(GHB,Xyrem,Alcover)an fibromyalgia

Claude de Contrecoeur patanie at
Sun May 23 22:05:35 EST 1999

J Rheumatol 1998 Oct;25(10):1986-90 

Effect of gamma-hydroxybutyrate on pain, fatigue,
and the alpha sleep anomaly in patients with
fibromyalgia. Preliminary report.

Scharf MB, Hauck M, Stover R, McDannold M, Berkowitz D

Center for Research in Sleep Disorders, Cincinnati, Ohio, USA. 

OBJECTIVE: To evaluate the effects of using a gamma-hydroxybutyrate
administered in divided doses at night in 11 patients previously
with fibromyalgia (FM). METHODS: Subjects completed daily diaries
their pain and fatigue levels and slept in the sleep laboratory before
one month after initiating GHB treatment. Polysomnographic recordings
evaluated for sleep stages, sleep efficiency and the presence of the
anomaly in non-REM sleep. RESULTS: There was a significant improvement
both fatigue and pain, with an increase in slow wave sleep and a
in the severity of the alpha anomaly. CONCLUSION: Further controlled
studies are needed to characterize the clinical improvement and the
polysomnographic changes we observed.

More information about the Neur-sci mailing list