Hi, James, your post gives me the most Awesomely-profound =Joy=. Good for you
and your colleagues, who've sought Truth... HURRAH+++***!!!
ken, Cheers to you James
>Subject: Re: New Nerve Transmitter Overturns Long-Cherished Laws
>From: james.teo at chch.ox.ac.uk (James Teo)
>Date: Wed, 10 November 1999 05:21 PM EST
>Message-id: <3829edc7.2366313 at news.freeserve.net>
>>>Using the term transmitter is awfully strong, since it seems to act
>only to modulate an existing transmitter's receptor.
>>However, it has long been known that glia releases some substances
>which are known to act as neurotransmitters. Adenosine, BDNF,
>aspartate, and my personal speciality: glutamate, the most common
>neurotransmitter in the whole brain. (Read my abstract in Teo et al
>Proceedings of the British Pharmacological Society, July 1999,
>page P83). Hopefully I might get a publication from that.
>>Anyways, as far as I am aware all of the studies have only been done
>in vitro, since it is impossible to distinguish between astrocyte
>release and neuronal release in in vivo models. Even some primary
>cultures are problematic, since they may be contaminated with
>neurones. My study is done on a immortal cell line (C6 glioma) so
>there is little fear of contamination.
>>Other references outlining the 'glial heresy' against the dogma of the
>neurone:
>Bezzi et al 1998, Nature 391, pages 281-285
>Jeftinija et al 1996, Journal of Neurochemistry 66(2), pages 676-684
>Parpura et al 1994, Nature 369, page 744-747
>Steinhauser & Gallo 1996, Trends in Neurosciences 19(8), pages 339-345
>Stella et al 1994, Journal of Neuroscience 14(2), pagesd 568-575
>Smith, S (1996) Current Biology (can't remember exactly)
