Copied from the webpage immediately above:
The Glutamate Cascade: Common Pathways of Central Nervous System Disease
To explore the evidence that the "glutamate cascade" appears to be
associated with several seemingly diverse disease processes of the CNS. The
related excitotoxic cascade has been demonstrated in some of these
processes. The hope is to stimulate a cross-fertilization of ideas in basic
brain mechanisms and preclinical and clinical medications development of
direct or indirect glutamatergic antagonists in diverse medical disciplines
which focus on these disorders.
Disorders in which a role for glutamate have been demonstrated include:
addiction (tolerance, sensitization, dependence, and/or neurotoxicity that
is associated with drugs of abuse including opiates, cocaine, amphetamine,
alcohol); stroke; epilepsy; brain trauma; certain types of neuropathic pain;
AIDS dementia; schizophrenia; depression; anxiety; and aging/Alzheimer's. A
role of NMDA receptor complex and NO has also been implicated in LTP and in
other models for learning and memory.
Read books by Arthur Janov if you'd care/dare to know precisely what "primal
pain" (or Pain) refers to.
Or, an perfectly synonymous alternative is CURSES. CURSES is a less "up
front confronting" but more "up your nose" concept that is part of an
unusually encompassing rational/philosophical scheme that is (may work as) a
science-aligned complementary explanation for (or rather unique and potent
concEPTual grasp on) just about everything about us humans (and more).
"CURSES" is derived and defined as per