Neural antigen presentation in Multiple Sclerosis

Theophilus Samuels theophilus.samuels at
Thu Apr 20 08:30:47 EST 2000

At present is is thought that T cell activation (in response to neural
antigens such as MBP) occurs in the periphery, lymph nodes etc, which then
allows them to penetrate the BBB and produce the crippling CNS inflammatory
response observed in MS patients. I ask the following question - how does
the neural antigen get into the peripheral lymphatic system in the first
place, since lymphatic vessels are not present in the CNS?


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