Neural antigen presentation in Multiple Sclerosis

Theophilus Samuels theophilus.samuels at
Sun Apr 23 05:26:32 EST 2000

>From the Experimental Biology 2000 meeting;

'...Dr. Popovich and colleagues stimulated T cells with myelin proteins and
injected them into animals with spinal cord injury. The treatment
significantly improved hind limb function, according to Dr. Popovich.

"Traditionally we've always thought of a T cell responding to nervous system
proteins as being bad," he said. "It's mostly because the methodology and
the models have been developed in the context of multiple sclerosis, which
is where T cells are typically causing damage. It's the context in which the
cells become activated that may dictate whether it's a protective or
detrimental effect."

Although these monocyte- and T cell-based treatments increased hind limb
function only by 10%, the researchers noted that this is comparable to the
effects of methylprednisolone, the current standard of therapy for spinal
cord injury in humans...'


Theophilus Samuels <theophilus.samuels at> wrote in message
news:8dn0qh$q3a$1 at
> At present is is thought that T cell activation (in response to neural
> antigens such as MBP) occurs in the periphery, lymph nodes etc, which then
> allows them to penetrate the BBB and produce the crippling CNS
> response observed in MS patients. I ask the following question - how does
> the neural antigen get into the peripheral lymphatic system in the first
> place, since lymphatic vessels are not present in the CNS?
>   T.L.S.

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