an ALS Hypothesis

dag.stenberg at helsinki.nospam.fi dag.stenberg at helsinki.nospam.fi
Wed Feb 2 03:54:43 EST 2000


kenneth Collins <kpaulc at earthlink.net> wrote:
> of course, if, contrary to the hypothesis i've been discussing, the
> 'lesion' is, in fact, a genetic 'lesion' that's distributed theougout
> the supersystem, then it seems that the only way to possibly attack the
> 'lesion' would be through globally-distributed chemo approach, with
> respect to which, i'm out of my depth.

> it's just that it doesn't seem to be globally-distributed because
> sensory fx is unaffected. 

A genetic lesion can be in all cells and still be expressed only in a
subsystem (target tissue, cell type or whatever). There has to be some
coincidence (like something specific to motor neurons that makes the
global lesion activate in them only).

Dag Stenberg




More information about the Neur-sci mailing list