an ALS Hypothesis
kpaulc at earthlink.net
Wed Feb 2 21:07:00 EST 2000
dag.stenberg at helsinki.nospam.fi wrote:
> kenneth Collins <kpaulc at earthlink.net> wrote:
> > of course, if, contrary to the hypothesis i've been discussing, the
> > 'lesion' is, in fact, a genetic 'lesion' that's distributed theougout
> > the supersystem, then it seems that the only way to possibly attack the
> > 'lesion' would be through globally-distributed chemo approach, with
> > respect to which, i'm out of my depth.
> > it's just that it doesn't seem to be globally-distributed because
> > sensory fx is unaffected.
> A genetic lesion can be in all cells
yes, if a genetic 'lesion' is in the DNA, then it can be in all cells.
> and still be expressed only in a
> subsystem (target tissue, cell type or whatever). There has to be some
> coincidence (like something specific to motor neurons that makes the
> global lesion activate in them only).
> Dag Stenberg
a hypothetical instance of a localized-'lesion' version of the last
stuff is, at the 'level' of the integrated Neuroanatomy and its
functioning, in the hypothesis i've been discussing.
i've agreed that the localized 'lesion' can be as genetic-susceptibility
stuff that's triggered via environmental (chemo, dietetic, etc. or
'fragility' with respect to 'normal' head trauma) factors.
i'm just working to show that there's probably more to the 'disease'
dynamics than has been considered to be the case.
k. p. collins
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