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Hippocampal Function

Brian Scott brians at echo-on.net
Sat Jan 1 05:01:51 EST 2000

dag.stenberg at helsinki.nospam.fi wrote:
> > Brian Scott <brians at interlog.com> wrote:
> > > I don't have the reference here but this group used the standard
> > > bromodeoxyuridine techniques for measuring cell division along with
> > > cell-type markers to show an increase in neurogenesis following
> > > administration of several antidepressants as well as ECS.  I think
> > > Druganow was one of the authors but I'm not sure.  I think their point
> > > was that neurogenesis may underlie some of the antidepressant effects of
> > > these treatments.
> You probably did not mean Jacobs' and Fornal's BrdU work, but the other
> one (but there was no Druganov):

Yes, that's the one.  I think they also had some data at their poster
showing the development of these cells into neurons...expressing
neuronal markers etc. several weeks later.  Is there a reliable
behavioural measure of the action of these drugs in an animal depression
model?  I'm curious to know if one wipes out the neuronal precursor
population (using external radiation for example), if this will affect
the antidepressant action of these drugs in an animal model.
I was not aware of Jacobs' and Fornal's abstract.  Thanks for pointing
it out.  


> abstract 413.6
> J.E.Malberg, A.J.Eisch, E.J.Nestler, R.S.Duman
> "Chronic antidepressant administration increases granule cell genesis in
> the hippocampus of the adult male rat".
> They gave ECS 1x/day for 4 or 10 d, or antidepressant drugs (14-21 d)
> including fluoxetine, tranylcypromine or reboxetine (NE selective uptake
> inhibitor). All the antidepressant treatments produced increases in the
> number of BrdU-positive cells in the dentate gyrus and hilus. Acute
> (1 d) fluoxetine did not. "The induction of neurogenesis may be one of
> the mechanisms by which antidepressants block the stress-induced atrophy
> and death of hippocampal neurons."
> The result is similar (although the description of method and result not
> as clear) to Jacobs's, the hypothesis too, although it was described
> more clearly by Jacobs. But Duman's review in Biol Psychiatry 1999 Nov
> 1;46(9):1181-91 is probably very clarifying.
> Dag Stenberg

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