> As a layman, I would like to know if there are different subgroups of
> NMDA-receptors in different parts of the human body. Most of all, I
> would like to know if the NMDA-receptors in the human cochlea differ
> from the NMDA-receptors in the brain. Is there any theoretical
> possibility to create an NMDA-antagonist that only works in the
> cochlea while avoiding side-effects in the brain?
Well, yes there are different NMDA receptor sub-types, and their
distribution does vary with developmental age and brain
location. As to what sort of NMDA receptors are present in the
cochlea I can't help you. Why do you want to know?
Dr Richard Vickery
School of Physiology & Pharmacology, UNSW, Australia, 2052
ph. 61 2 93851676, fax 61 2 93851059