neurogenesis - NewSci Feb 12 2000

jan jan at aglow.demon.co.uk
Thu Mar 23 08:46:26 EST 2000


  Hello Boris777,


>please email or post if you'd like references for what i've written (i
                 ^^^^
>don't have them nearby right now).

   That would be good of you. I`m sure I won`t be the only one  
    interested.


>i hope we find that the best ways to stimulate neurogenesis are not
>through pharmacological intervention, but that's my own view...

   Useful maybe to persuade people who need them to take/stay on SSRI`s 
  (As in `And, Winifred, they`re good for your brain, too!`)


In article <8b6ill$9nf$1 at nnrp1.deja.com>, boris777 at my-deja.com writes
>In article <38D333EC.186DFBE8 at primus.com.au>,
>Ian McLeod <ian_mcleod at primus.com.au> wrote:
>>
>>
>> Brian Scott wrote:
>>
>> This is not good news for the drug education bodies. Does this mean that
>> drugs such as amphetamines can actually help people? Or am I mistaking
>> amphetamines for something else?
>
>amphetamines have a decidedly non-neurogenetic effect.  methamphetamine
>is one of the more potent serotonergic and dopaminergic neurotoxins.
>its neurotoxic properties appear to have more to do with free radical
>generation than its ability to stimulate serotonin or dopamine release.
>
>
>>
>> Could we facilitate neurogenesis without drugs? Meditation, anything that may
>> reduce stress and increase seratonin.
>>
>> >
>> > R.S. Duman reported at a recent Society for Neuroscience meeting that
>
>i worked next door to ron duman from 1998-1999 and the theory that was
>emerging from the lab was that ECS and SSRIs stimulate CREB mediated
>transcription of Brain Derived Neurotrophic Factor (BDNF) which has
>rather well-documented neuroprotective ability, and may also be
>implicated in neurogenesis, though that latter link still appears to be
>weak.
>
>also, fred gage's group has shown that simply running (in rats) or
>living in an environment with more varied stimulation than a stainless
>steel cage will increase neurogenesis too....i hope we find that the
>best ways to stimulate neurogenesis are not through pharmacoligcal
>intervention, but that's my own view...
>
>please email or post if you'd like references for what i've written (i
>don't have them nearby right now).
>
>peas,
>boris
>
>> > several antidepressant drugs as well as electroconvulsive shock also
>> > increase neurogenesis in the dentate gyrus. It's likely that anything
>> > that increases serotonin action will increase neurogenesis by an effect
>> > on proliferation of the progenitor cells.
>> >
>> > --
>> >
>> > Brian Scott
>> > brians at eol.ca
>> > brians at interlog.com
>> >
>> > "In other studies you go as far as others have gone before you, and
>> > there is nothing more to know; but in scientific pursuit there is
>> > continual food for discovery and wonder." - Victor Frankenstein
>> > (from Mary Shelley's Frankenstein, 1818)
>>
>>
>
>
>Sent via Deja.com http://www.deja.com/
>Before you buy.

-- 
jan




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