nerve regeneration question

Fengquan Zhou fzhou at
Tue Mar 28 12:19:35 EST 2000

I am wondering if anybody knows the answer.

After nerve is injured, in order to regenerate, a growth cone formation
is necessary. In vitro experiments shows that after the axon is severed,
it seals its membrane and swells to form a stump end. Then a growth cone
is formed from the stump followed by new neurite outgrowth from this
growth cone. Is this true also in vivo? or the new neurite can grow out
from the axonal stump directly without forming a growth cone first?



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