Depression / SSRI Mechanics

dag.stenberg at nospam.helsinki.fi dag.stenberg at nospam.helsinki.fi
Fri Nov 30 05:44:35 EST 2001


Ian Goddard <igoddard at erols.mom> wrote:
>
>   SSRIs suppress activity in the frontal cortex.
> 

It was the other way round, wasn't it?
SSRIs desensitized the inhibitory autoreceptors, ehnancing 5HT release
in the frontal cortex:

> ==================================================================
> SSRIs DESENSITIZE 5-HT AUTORECEPTORS IN THE ORBITAL-FRONTAL CORTEX
> ==================================================================
> Neuropsychopharmacology 1995 Oct;13(2):117-27 
> ...
> evoked release of [3H]5-HT release was enhanced in the frontal cortex
> (21%) but not in the orbito-frontal cortex or in the head of caudate
> nucleus. However, after an 8-week treatment, the evoked release of
> [3H]5-HT was significantly enhanced in the orbito-frontal cortex (55%)
> and in the rest of the frontal cortex (29%) from the same animals ...

So you have to rework the hypothesis.

Dag Stenberg




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