Depression / SSRI Mechanics
igoddard at erols.mom
Fri Nov 30 13:20:26 EST 2001
On 30 Nov 2001 10:44:35 GMT, dag.stenberg at nospam.helsinki.fi wrote:
>Ian Goddard <igoddard at erols.mom> wrote:
>> SSRIs suppress activity in the frontal cortex.
>It was the other way round, wasn't it?
>SSRIs desensitized the inhibitory autoreceptors, ehnancing 5HT release
>in the frontal cortex:
IAN: Good point. However, I think this is not contrary
to the thesis since it is said that 5-HT can act as a
suppressor of other neurological activities. In which
case your point refines how the thesis is presented.
Supporting an SSRI-induced decrease in frontal-lobe activity
is research by Dr Leuchter, UCLA Neuropsychiatric Institute:
"By placing electrodes on the scalp, Dr. Leuchter and
colleagues found that people who improved on Prozac
showed a decrease in activity in the front of the brain."
Those findings were released at a conferences, not sure
if they've been published yet. Will look into the matter.
Assuming the findings true, they suggest the concurrent
enhanced release of 5-HT decreases overall activity.
That research also found that those who got better on
placebo showed increased frontal-lobe activity, which
would tend to complicate the thesis. However, I suspect
based on that and/or similar research that the effect
of SSRIs would be attributed at least in theory to
being a product of reducing frontal-lobe hyperactivity.
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