DHEA for Mental Function in Advanced AIDS
James Michael Howard
jmhoward at sprynet.com
Wed Oct 10 11:29:38 EST 2001
It is my hypothesis that the symptoms of AIDS result from the loss of DHEA of
AIDS. Here is a new abstract showing usefulness of DHEA in "mental funcion" in
"patients with advanced HIV disease."
Clin Endocrinol (Oxf) 2001 Sep;55(3):325-330
"Double-blind placebo-controlled trial of oral dehydroepiandrosterone in patients
with advanced HIV disease"
Piketty C, Jayle D, Leplege A, Castiel P, Ecosse E, Gonzalez-Canali G, Sabatier B,
Boulle N, Debuire B, Le Bouc Y, Baulieu EE, Kazatchkine MD.
"OBJECTIVE: Plasma levels of dehydroepiandrosterone sulphate (DHEA-S) decrease
with the progression of HIV disease. Here, we report on the efficacy and safety of
the oral administration of DHEA as replacement therapy, in patients with advanced
HIV disease, in a trial that was primarily aimed at assessing quality of life.
DESIGN: The trial was randomized and double-blind. Thirty-two patients were
allocated to either DHEA 50 mg per day for 4 months (n = 14) or a matching placebo
(n = 18). Clinical data, virological and immunological surrogate markers of HIV
infection, plasma levels of DHEA-S and the Medical Outcomes Study HIV Health
Survey (MOS-HIV) quality of life scale were recorded every month. RESULTS: The
mean age of the patients was 40 +/- 11 years. The mean CD4 cell count at baseline
was 32.5 +/- 32.4 x 106/l. The mean DHEA-S plasma level at baseline was 5.23 +/-
0.76 &mgr;mol/l. No side-effects related to DHEA occurred during the study. A
statistically significant increase in the levels of DHEA-S was observed in the
treated group throughout the study (P < 0.01). A significant improvement in the
Mental Health and Health Distress dimension of MOS-HIV was observed in the DHEA
treated group; P = 0.001 and 0.004, respectively. No change in CD4 cell counts was
seen during follow-up. CONCLUSIONS: The administration of DHEA in patients with
advanced HIV infection results in improved mental function scores as assessed by
the MOS-HIV quality of life scale."
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