Increased blood flow detected by fMRI scans?

Brian zhil at online.no
Sun Oct 28 09:25:13 EST 2001


"Richard Norman" <rsnorman at mediaone.net> skrev i melding
news:pn6mttgh7tlsuhls4fb1efq65klvb53cca at 4ax.com...
> On Sat, 27 Oct 2001 20:10:05 +0200, "Brian" <zhil at online.no> wrote:
> >If you can find a way to increase the production of CREB-1, you'll solve
> >most problems.
> >(CREB-1 initiates the production of synapses, and hence to enhance
memory.
> >forget glutamate and other synaptic messengers).
> >
> >Brian
> >
> >> John H.
> >
>
> Lets see, now.
>
>  According to http://www.stanford.edu/~ewilhelm/Cumulus/CREB1.htm
> CREB1 is involved in Ovarian follicle growth and/or maturation,
> Follicle atresia, Ovulation, Steroidogenesis, Luteinization .
>
> And http://www.lf2.cuni.cz/physiolres/2000/issue3/iss3cl10.htm
> talks about CREB1 in T-lymphocytes stimulated by prostaglandin.
>
> And http://www.socgenmicrobiol.org.uk/JGV/081/1057/0811057H.HTM
> says that CREB1 is involved in activation of Epstein-Barr virus.
>
> And
>
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=10873779&dopt=Abstract
> involves CREB1 in linkage between stress and human cytomegaolvirus
> infection.
>
> See be careful what you ask for!

CREB-1: in "Memory" they're calling it 'the cAMP-response element binding
protein-1'
Quote:"It is the action of the phosphorylated form of CREB-1 that switches
on the genes needed to form long-term memory."

Brian

Excerpts general:
"Following hormonal stimulation of a neuroendocrine cell, forexample,
increased cAMP levels activate cAMP-dependent protein kinase A, which
phosphorylates 1 or moreDNA-binding proteins. These in turn stimulate
transcription of an array of cAMP-responsive genes. All cAMP-responsive gene
promoters have in common an 8-base enhancer known as the cAMP-response
element (CRE)containing a conserved core sequence, 5-prime-TGACG-3-prime,
first described in the somatostatin gene by Montminy et al. (1986). Montminy
and Bilezikjian (1987) purified a 43-kD nuclear phosphoprotein, which binds
to CRE with highaffinity.Transcriptional activity of CREB requires
phosphorylation of the protein on a serine residue at position 119. "

Last, I was thinking of the process IN the neuron, not in the ovarian
granulosa cells................





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