Stray-thoughts about LT and ST memory.

John H. John at
Fri Sep 21 04:20:45 EST 2001

Okay, I have my suspicions about something as 'generic' calmodulin but
thought this might help you along. Also note that they could not knock out
Creb .... .

Researchers Find Enzyme Crucial to Preservation of Memories

September 21, 2001— Using a technique to eliminate the function of one
enzyme in a restricted memory-related region in the brains of mice,
researchers have shown that the enzyme is important in consolidating
long-term memories.

John H.

Brian wrote in message ...
>Hello John,
>"John H" <John at> skrev i melding
>news:62np7.1074$pk3.50331 at
>> Nuerite extension happens through a very complicated process involving a
>> plethora of intra and extra cellular signs and wonders. If you wish to
>> understand it at the molecular level then you have some reading ahead of
>> you, and also a multitude of problems because much remains unknown.
>> The process of synaptic strengthening and new formation can commence in
>> minutes but may take several hours to complete. You might want to look at
>> the work of Eric Kandel. Short term memory can be facilitated through
>> intracellular mechanisms, long term memory seems to require a specific
>> genetic transcription mechanism. Biologically two separate things.
>Thanks for the reference.
>I found "Memory" by Larry R. Squire, Eric R. Kandel.
>Seems to be the right one, and it is published May 2000.
>> You also might want to remember the strange business of 'silent synapses'
>> particularly prevalent in the hippocampal regions I believe. My belief,
>> shared by others, is that these 'ready to go' synapses allow the rapid
>> creation of pathways without a whole lot of lengthy and complicated
>> metabolism. Silent synapses are much more prevalent at birth, decline
>> age, if studies are to be believed. I think these little buggers may
>> important insights into why we can learn some things very quickly
>> (especially via the amygdala). Don't know much about silent synapses but
>> others here may be able to help.
>> Finally, when neurite extension occurs and the various membrane changes
>> occur, surrounding synapses also may receive boost from an overflow
>> of trophic factors etc.
>> Hope this helps,
>It did, thank you very much.

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