THC is Neuro-Protective

Chuck chuckfrasher at yahoo.com
Sat Jan 12 23:13:45 EST 2002


igoddard at erols.mom (Ian Goddard) wrote in message news:<3c3dc869.138850691 at news.erols.com>...
> Journal of Neuroscience, 2001 Sep 1;21(17):6475-9.
> 
> "...Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the 
> main active compound in marijuana, reduces neuronal 
> injury in neonatal rats ...  These results provide 
> evidence that the cannabinoid system can serve to 
> protect the brain against neurodegeneration."
> 
> http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11517236&dopt=Abstract
> 
> *******************************************************
> 
> Brain Research, 2000 Feb 28;857(1-2):183-7.
> 
> "The high dose THC-treated group showed significantly 
> less neocortical injury, compared to either the control 
> or low-dose THC groups (p<0.05). The striatum was markedly 
> protected by both low and high dose THC (p<0.001)."
> 
> http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10700566&dopt=Abstract
> 
> ************************************************************
> 
> Annals of the New York Acadamy of Sciences, 2000;899:274-82.
> 
> Neuroprotective antioxidants from marijuana.
> 
> "...cannabinoids can act as an antioxidants in neuronal 
> cultures ... In a head to head trial of the abilities 
> of various antioxidants to prevent glutamate toxicity, 
> cannabidiol was superior to both alpha-tocopherol 
> [vitamin E] and ascorbate [vita C] in protective capacity."
> 
> http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10863546&dopt=Abstract
> 
> ***********************************************************
> 
> Neuroscience Letters, 2001 Aug 31;309(3):197-201.
> 
> "Addition of Delta(9)-tetrahydrocannabinol [THC] to the culture 
> medium attenuated the toxicity produced by kainate. ... The
> neuroprotective effect was blocked with the CB(1) receptor 
> antagonist, SR141716A, indicating a receptor-mediated effect."
> 
> http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11514075&dopt=Abstract
> 
> *************************************************************
> 
> Proc Natl Acad Sci U S A, 1998 Jul 7;95(14):8268-73.
> 
> Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective
> antioxidants.
> 
> "Cannabidiol and THC also were shown to prevent hydroperoxide-
> induced oxidative damage as well as or better than other 
> antioxidants in a chemical (Fenton reaction) system and 
> neuronal cultures. Cannabidiol was more protective against 
> glutamate neurotoxicity than either ascorbate or alpha-
> tocopherol, indicating it to be a potent antioxidant."
> 
> Full Study: http://www.pnas.org/cgi/content/full/95/14/8268
> http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9653176&dopt=Abstract
> 
> ************************************************************
> 
> J Pharmacol Exp Ther, 2000 Jun;293(3):807-12.
> 
> Cannabinoids protect cells from oxidative cell death: 
> a receptor-independent mechanism.
> 
> "...submicromolar concentrations of Delta(9)-tetrahydrocannabinol
> (THC), Delta(8)-THC, cannabinol, or cannabidiol ... prevented
> serum-deprived cell death. ... The antioxidative property of
> cannabinoids was confirmed by their ability to antagonize 
> oxidative stress and consequent cell death induced by the 
> retinoid anhydroretinol. Therefore, cannabinoids act as 
> antioxidants to modulate cell survival and growth of 
> B lymphocytes and fibroblasts."
> 
> http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10869379&dopt=Abstract
> 
> ************************************************************
> 
> NOTE: There are numerous studies that show THC IMPAIRS MEMORY.
> However, while unacceptable to myself, such impairment resolves
> within 24 hours of acute use and a couple weeks after chronic use.
> Such impairment appears to be caused by reduction of acetylcholine.

How about vasopressin?




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