Motor control - post surgical removal of brain

Kalman Rubinson kr4 at nyu.edu
Thu Jan 17 10:09:54 EST 2002


On Thu, 17 Jan 2002 22:27:55 +1300, "yan king yin" <y.k.y@(dont
spam)lycos.com> wrote:

>Sorry -- I have made a mistake by extrapolating too much. I thought
>if dopamine neurons were transplanted to the substantia nigra they
>would project to the putamen (their normal target). But it turns out this
>might not actually happen.

I do not know of this happening.  The human procedures I heard of
involved implanting the DA neurons in the the putamen so they need not
have to find their way there.

>In another study by Bjorklund, they showed that embryonic DA cells
>transplanted to the substantia nigra will reconnect with the striatum if
>it is done in young rats (postnatal day 10) but not older (P20). Could
>it be that the molecular cues for axonal guidance are still secreted by
>the targets in P10 but no longer in P20? That would be bad news =(

It may be since it is likely that there's more than one cue involved
in such a complex projection.

Kal




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