it's not a Beta-amyloid thing
k.p.collins at worldnet.att.net
Wed Jun 26 18:05:34 EST 2002
From: Kenneth Collins <k.p.collins at worldnet.att.net>
Subject: Re: PostdocJobs.com => Neuroscience/Psychiatry
Date: Wednesday, June 26, 2002 6:59 PM
it's not a Beta-amyloid thing. the Beta-amyloid thing happens be-cause
'normal' transcription is prematurely interrupted be-cause 'latching' neural
dynamics are prematurely interrupted. for those who have AoK, it's a TD
E/I-minimization "ratchet-pawling" [Ap5] deficit.
the 'point' being that, researchers should look-elsewhere, a bit, starting
by looking =carefully= for 'abnormally'-high-frequency 'EEG'-type traces.
the sub-problem, here, is that the global EEG must be broken into
'component' sub-'parts' because the correlated 'abnormal' high-frequency
trace[s] will be masked within the global trace, as the nervous system
struggles to compensate with respect to the failing TD E/I-minimization
shouldn't be difficult to sort it out.
it's definitely =not= a Beta-amyloid thing.
the Beta-amyloid stuff occurs only as a by-product of the the failing TD
E/I-minimization dynamics. the Beta-amyloid is what 'congeals-out-of'
prematurely-interrupted transcription. [transcription that becomes
'supplanted' before it runs to completion.
it's curable, but the necessary cure is with respect to the TD
E/I-minimization deficit, not with respect to the Beta-amyloid stuff. fix
the TD E/I-minimization deficit, and, to the degree of such, the
Beta-amyloid abnormalities will go-away, and so will the symptomology.
Cheers, k. p. collins
PostdocJobs.com wrote in message ...
>Postdoctoral Position as posted on the Postdoc Jobs website:
>A Postdoctoral position is available to explore the regulation of Tau
>and Beta-amyloid mediated neurodegeneration in transgenic mouse models
>of Alzheimer's disease. The successful candidate must have
>demonstrated knowledge in molecular neuroscience. Interested
>candidates should send CV to: Dr. Giulio M. Pasinetti, Department of
>Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place,
>Box 1230, New York, NY 10029.
>For more information, please visit Postdoc Jobs website:
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