CR vs Brain Cancer

Ian Goddard igoddard at erols.mom
Fri Jun 28 03:03:18 EST 2002


Br J Cancer  2002 May 20;86(10):1615-21 

Dietary restriction reduces angiogenesis and growth in an 
orthotopic mouse brain tumour model.

Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN.

Biology Department, Boston College, Chestnut Hill, Massachusetts, 
MA 02467, USA.

Diet and lifestyle produce major effects on tumour incidence, 
prevalence, and natural history. Moderate dietary restriction has 
long been recognised as a natural therapy that improves health, 
promotes longevity, and reduces both the incidence and growth of 
many tumour types. Dietary restriction differs from fasting or 
starvation by reducing total food and caloric intake without 
causing nutritional deficiencies. No prior studies have evaluated 
the responsiveness of malignant brain cancer to dietary 
restriction. We found that a moderate dietary restriction of 
30-40% significantly inhibited the intracerebral growth of the
CT-2A syngeneic malignant mouse astrocytoma by almost 80%. The 
total dietary intake for the ad libitum control group (n=9) and 
the dietary restriction experimental group (n=10) was about 20 
and 13 Kcal day(-1), respectively. Overall health and vitality 
was better in the dietary restriction-fed mice than in the ad 
libitum-fed mice. Tumour microvessel density (Factor VIII
immunostaining) was two-fold less in the dietary restriction 
mice than in the ad libitum mice, whereas the tumour apoptotic 
index (TUNEL assay) was three-fold greater in the dietary 
restriction mice than in the ad libitum mice. CT-2A tumour cell-
induced vascularity was also less in the dietary restriction mice
than in the ad libitum mice in the in vivo Matrigel plug assay. 
These findings indicate that dietary restriction inhibited CT-2A 
growth by reducing angiogenesis and by enhancing apoptosis. 
Dietary restriction may shift the tumour microenvironment from 
a proangiogenic to an antiangiogenic state through multiple 
effects on the tumour cells and the tumour-associated host cells.
Our data suggest that moderate dietary restriction may be an 
effective antiangiogenic therapy for recurrent malignant brain 
cancers. DOI: 10.1038/sj/bjc/6600298 www.bjcancer.comCopyright 
2002 Cancer Research UK

PMID: 12085212 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12085212&dopt=Abstract


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