CR vs Brain Cancer

Kenneth Collins k.p.collins at
Fri Jun 28 14:39:26 EST 2002

there are a lot of 'loose-ends' in what, i agree, is a general approach that
needs to be explored.

the first thing that needs to be kept in mind is that simple
calorie-restriction doesn't prolong Life [Africa, North Korea], so, perhaps
what's happening is that calorie-reduction induces an organism to
range-more-widely with respect to what it will accept as 'food', and that
it's such wide-ranging-ness that results in bringing micronutrients into a
system that would've, otherwise, taken-the-easy-route with respect to
'food'... just eat what's there-in-abundance, missing the micronutrients
that're not-there, within the abundance.

lab subjects, for instance, might ingest wood-shavings stuff, for instance,
and there might be something in-there that is what makes the difference.

i'm not saying that the ingestion of wood-shafvings stuff =is= what's

i just wanted to point out all the loose-ends stuff that needs to be

for instance, it's a virtual certainty that humans who choose to 'restrict'
calorie intake do not just restrict calorie intake. they simultaneously
choose better foods, containing a wider range of nutrients.

anyway, Cheers, Ian, ken [k. p. collins]

Ian Goddard wrote in message <3d1c1782.25504536 at>...
>Br J Cancer  2002 May 20;86(10):1615-21
>Dietary restriction reduces angiogenesis and growth in an
>orthotopic mouse brain tumour model.
>Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN.
>Biology Department, Boston College, Chestnut Hill, Massachusetts,
>MA 02467, USA.
>Diet and lifestyle produce major effects on tumour incidence,
>prevalence, and natural history. Moderate dietary restriction has
>long been recognised as a natural therapy that improves health,
>promotes longevity, and reduces both the incidence and growth of
>many tumour types. Dietary restriction differs from fasting or
>starvation by reducing total food and caloric intake without
>causing nutritional deficiencies. No prior studies have evaluated
>the responsiveness of malignant brain cancer to dietary
>restriction. We found that a moderate dietary restriction of
>30-40% significantly inhibited the intracerebral growth of the
>CT-2A syngeneic malignant mouse astrocytoma by almost 80%. The
>total dietary intake for the ad libitum control group (n=9) and
>the dietary restriction experimental group (n=10) was about 20
>and 13 Kcal day(-1), respectively. Overall health and vitality
>was better in the dietary restriction-fed mice than in the ad
>libitum-fed mice. Tumour microvessel density (Factor VIII
>immunostaining) was two-fold less in the dietary restriction
>mice than in the ad libitum mice, whereas the tumour apoptotic
>index (TUNEL assay) was three-fold greater in the dietary
>restriction mice than in the ad libitum mice. CT-2A tumour cell-
>induced vascularity was also less in the dietary restriction mice
>than in the ad libitum mice in the in vivo Matrigel plug assay.
>These findings indicate that dietary restriction inhibited CT-2A
>growth by reducing angiogenesis and by enhancing apoptosis.
>Dietary restriction may shift the tumour microenvironment from
>a proangiogenic to an antiangiogenic state through multiple
>effects on the tumour cells and the tumour-associated host cells.
>Our data suggest that moderate dietary restriction may be an
>effective antiangiogenic therapy for recurrent malignant brain
>cancers. DOI: 10.1038/sj/bjc/6600298 www.bjcancer.comCopyright
>2002 Cancer Research UK
>PMID: 12085212 [PubMed - in process]
>  "To lengthen thy life, lessen thy meals." Ben Franklin
>  Caloric Restriction:

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