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Sundowning: severe dementia and bringing on the night (corticosterone increases aggression in the rat)

John H. johnh at faraway.xxx
Wed Apr 2 18:32:13 EST 2003


I suggest you start rehearsing Hegel's lament.


John.
"KP-PC" <k.p.collins at worldnet.att.net%remove%> wrote in message
news:c1Gia.10832$cO3.692478 at bgtnsc04-news.ops.worldnet.att.net...
> Hi John.
>
> This stuff is 'just' one 'superficial' observable with respect to
> underpinning global-system TD E/I - "Corticosterone fluctuations"
> [and everything else that happens within nervous systems] 'rides' TD
> E/I.
>
> That is, TD E/I is the base-'language' of nervous systems, and
> everything else is 'just' "functionally-multiplexed" stuff [AoK, Ap9]
> through which TD E/I-minimization is optimized in rigorous
> inverse-accord with the one-way flow of energy from order to disorder
> that is what's described by 2nd Thermo [WDB2T].
>
> Through TD E/I-minimization, nervous systems converge upon cognition,
> affect, and behavior that 'climbs' the WDB2T energy-gradient, which
> is functional because 'climbing' the WDB2T energy-gradient enables
> Life to 'move toward' increasing energy abundance.
>
> The 'tragic flaw' [AoK, Ap4], inherent, is that the correlated
> information-processing tends to be 'blind' to the fact that what
> constitutes the WDB2T energy-gradient occurs as a function of
> experience - tends to be 'blind' to the fact that behaviors coverged
> upon within relatively-mutually-exclusive experience tend to,
> themselves, 'interfere' with nervous systems' abilities to 'discern'
> directionalities within the overall WDB2T energy-gradient.
>
> The solution to this 'tragic flaw' problem is to experience =widely=.
>
> When this's done, to the degree that it is done, directionality
> within the overall WDB2T energy-gradient becomes discernable.
>
> Which is how I know that "Corticosterone fluctuations" [and
> everything else that happens within nervous systems] 'rides' TD E/I
> :-]
>
> Cheers, John.
>
> ken collins
>
> "John H." <johnh at faraway.xxx> wrote in message
> news:oLCia.311$an3.12677 at nnrp1.ozemail.com.au...
> | 3/04/03 12:46am
> |
> | J Neuroendocrinol 2000 Oct;12(10):937-40Related Articles, Ultradian
> | corticosterone rhythm and the propensity to behave aggressively in
> male
> | rats.
> |
> | Haller J, Halasz J, Mikics E, Kruk MR, Makara GB.
> |
> | Institute of Experimental Medicine, Budapest, Hungary.
> haller at koki.hu
> |
> | Ultradian fluctuations in plasma glucocorticoids have been
> demonstrated in a
> | variety of species including humans. The significance of such
> rhythms is
> | poorly known, although disorganized ultradian glucocorticoid
> rhythms have
> | been associated with behavioural disorders. Here we report that
> ultradian
> | glucocorticoid rhythms may establish the propensity to behave
> aggressively
> | in male rats. Male rats were significantly more aggressive in the
> increasing
> | phase of their corticosterone fluctuation when confronting a male
> intruder
> | than counterparts in the decreasing phase of their corticosterone
> | fluctuations facing such opponents. Corticosterone fluctuations
> were
> | mimicked by a combination of treatments with the corticosterone
> synthesis
> | inhibitor metyrapone and corticosterone. Again, males with
> increased plasma
> | corticosterone levels were more aggressive than counterparts with a
> | decreased plasma corticosterone concentration. These data suggest
> that the
> | behavioural response to an aggressive challenge may vary in the
> same animal
> | across the day due to the pulsating nature of corticosterone
> secretion.
> | Aggressive behaviour is also episodic in humans; moreover,
> intermittent
> | explosive behaviour is recognized as a psychological disorder. It
> can be
> | hypothesized that a temporal coincidence between the occurrence of
> a
> | challenge and a surge in plasma corticosterone concentration may be
> one of
> | the factors that promote episodic aggressive outbursts.
> |
> | PMID: 11012834 [PubMed - indexed for MEDLINE]
> |
> | "Dag Stenberg" <dag.stenberg at nospam.helsinki.fi.invalid> wrote in
> message
> | news:b6egod$62b$1 at oravannahka.helsinki.fi...
> | > In bionet.neuroscience BilZ0r <BilZ0r at takethisouthotmail.com>
> wrote:
> | > (About Ken P Collins' AoK)
> | > > I've been idling in the newgroup for some time, and I keep
> seeing you
> | use
> | > > this terminology. (TD E/I, AoK, Ap8).  I'm a pharmacologist,
> (although
> | I've
> | > > done a lot of neurosciency papers) and I'm just bout to start
> my
> | masters,
> | > > but I've never come across those ... Acronyms? Are they
> standard or just
> | > > something you made up?
> | >
> | > These are KPC:s abbreviations of a theory he designed himself.
> The AoK
> | > (Automation of Knowing) is a DOS-based hyperbase document
> comprising in
> | unzipped
> | > form 1.18 Mb of disk space. Ap8 etc. refer to chapters in this
> | > hypertext. TD E/I is a quantity which is crucial to the theory.
> | > To my knowledge KPC has not really received any support from
> scientists
> | > for his theory. AoK has consequently not been published in the
> | > conventional way, but I am sure Ken would email you a copy if you
> are
> | > interested in looking at it seriously.
> | >
> | > Dag Stenberg
> |
> |
>
>





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