IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP

Basic Neuron Questions

BilZ0r BilZ0r at TAKETHISOUThotmail.com
Sat Apr 12 18:55:46 EST 2003


"Didier A. Depireux" <didier at tango.isr.umd.edu> wrote in
news:b7a69u$jhr$1 at grapevine.wam.umd.edu: 

> John H. <johnh at faraway.xxx> wrote:
> 
>> "Cortical neurons receive 3000-10,000 synaptic contacts, 85% of which
>> are asymmetric and     hence presumably excitatory...Absent any
>> inhibition, a 
> 
> There's a lot more to the story than the number of synapses, there's
> also the physical location of the synapse. Those from fibers arising
> from thalamus and providing primary input tend to be close to the cell
> body, and large. Therefore a single EPSP from a thalamic input is a
> lot more effective than a large number of synapses being activated in
> the distal part of the dendritic tree. There are also shunting
> synapses etc, so you need more than just number of synapses before
> making these sweeping statements. 
> 
>                               Didier
> 

...and of course theres more to it that that. The density of receptors, 
the level of G-protein coupling, the propensity for activting and 
inactivating phosphylation 



More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net