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Alzheimer's protein jams mitochondria of affected cells; resulting 'energy crisis' kills neurons

KP-PC k.p.collins at worldnet.att.net%remove%
Wed Apr 23 02:30:21 EST 2003


I stand on what I've posted [dating back close to 5 years].

Cheers, Kim,

K. P. Collins

"Kim" <kim at nopsamclara.co.uk> wrote in message
news:Xns936653D8480FCkimnopsamclaracouk at 62.253.162.105...
| Hi KP,
| I would have to give my opinion on the cause of AD and I would say
that it
| has nothing to do with any transcription faults. All the proteins
are all
| ready present and working in healthy individuals, in people with AD
one of
| the proteins (APP) is simply processed another way, by another
enzyme which
| is already present (BACE) leading to the increased production of
the toxic
| peptide (ABP). The questions now are how does this peptide kill
neurons,
| which I would say involves calcium disruption through ABP pores and
ROS
| production (which arises from ABP interactions with the
mitochondria), and
| why is this harmful peptide produced in old age, which I would
suggest was
| due to cells adapting to the altered environment of the aged brain,
with
| particular attention to oxygen content.
|
| Just my opinions,
| Kim
|





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