1: J Natl Cancer Inst 1987 Nov;79(5):1059-65 Related Articles, Links
Opioid receptors and endogenous opioids in diverse human and animal cancers.
Zagon IS, McLaughlin PJ, Goodman SR, Rhodes RE.
Department of Anatomy, Milton S. Hershey Medical Center, Pennsylvania State
University, Hershey 17033.
Receptor binding studies demonstrated specific high-affinity, saturable
binding of a number of opioid ligands to a wide variety of neural and
nonneural human and animal tumors. Radioimmunoassays revealed the presence
of beta-endorphin and methionine-enkephalin in these tumors. Both
methionine- and leucine-enkephalin were detected in tumor tissue by
immunocytochemistry, with immunoreactivity related to the cortical cytoplasm
of tumor cells, but not to cell nuclei. Endogenous opioids and receptors
were found in benign and malignant tumors representative of ectodermal,
mesodermal, and endodermal origin. Receptors and endogenous opioid peptides
were present in tumors from many different species, including those
transplanted into nude mice. These results suggest that opioid receptors and
endogenous opioids are fundamental features of human and animal cancers.
PMID: 2824913 [PubMed - indexed for MEDLINE]