cocaine self-administration and yoking

Glen M. Sizemore gmsizemore2 at
Thu Aug 28 17:33:44 EST 2003

The effects of drugs depend on the behavioral context. A more important
question is why you think that the SA rat and the yoked-cocaine rat would
show the same effects.

"Christopher" <papillae at> wrote in message
news:410b1d29.0308280552.78490a87 at
> I read about the following study from and it
> really confused me, could anyone suggest an explanation for this
> effect ?:
> O I recently read about a fascinating study concerning administration
> of cocaine in rats. They had two
> O isolated experimental chambers, one rat in each, each animal
> supplied with an intravenous line through
> O which the drug could be injected. The guy in the top chamber
> received a dose every time he pushed a lever
> O in his experimental chamber (FR1 schedule) whereas the guy in the
> bottom chamber was yoked to the one on
> O top - he received a dose whenever the guy on top did completely
> independent of his own actions. It turned
> O out that with this setup, the guy on top was happily pushing the
> lever and the world seemed perfect
> O whereas the yoked rat was in a miserable situation unable to cope
> with this uncontrollable schedule
> O (mutilating etc). And when they did exactly the same experiment with
> delivery of sucrose pellets instead
> O of cocaine both rats were fine. Absolutely mind-blowing !!!
> - Christopher
> P.S. Does it apply to humans ?

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