cocaine self-administration and yoking

Glen M. Sizemore gmsizemore2 at yahoo.com
Sat Aug 30 08:58:10 EST 2003


DA goes up in the Nacc in yoked control rats, but it doesn't go up as much
as the SA rats.

"BilZ0r" <BilZ0r at TAKETHISOUThotmail.com> wrote in message
news:Xns93E79E5BC853ABilZ0rhotmailcom at 202.20.93.13...
> Whats also interesting, is that under these situations, dopamine (DA) is
> not release in the Nucleus Accumbens (NAc).
>
> I was lucky enough to hear a lecture by Prof Michael Joseph from the
> School of Psychology, University of Leicester, who is an expert on
> intercranial dialysis recordings of NAc DA activity. He commented on an
> experiment, where, instead of another rat controlling the dosing regiem,
> it was a human, and in this experiment, during the first couple random
> human controlled doses, there was DA release, but then from then on it
> ceased.
>
> papillae at anythingirish.ie (Christopher) wrote in
> news:410b1d29.0308290209.2e068e1e at posting.google.com:
>
> >> The effects of drugs depend on the behavioral context. A more
> >> important question is why you think that the SA rat and the
> >> yoked-cocaine rat would show the same effects.
> > The effects should be the same as the reinforcement value of the drug
> > remains constant. Why is it that denying instrumental control over
> > delivery of food pellets does not exhibit the effect described whereas
> > noncontingent injection of cocaine (yoking) does ???
> >
> > - Christopher
> >
> > P.S. Btw do rats find injection of sucrose solution rewarding ?
> >
>





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