cocaine self-administration and yoking

Christopher papillae at anythingirish.ie
Sat Aug 30 15:49:55 EST 2003


> Your view of drug effects seems to be hopelessly naive. 
Thanks for the encouragement !

> matter is that there are a host of drug effects that dependent on the
> behavioral context. It is nonsense to ask about the effects of drugs without
> specifying the context in which the drug is administered.
Good point !!! But the question still remains why the effects are so
different across the two different conditions ???

- Christopher


> > I read about the following study from www.hedweb.com/forum/ and it
> > really confused me, could anyone suggest an explanation for this
> > effect ?:
> >
> > OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
> > O I recently read about a fascinating study concerning administration
> > of cocaine in rats. They had two
> > O isolated experimental chambers, one rat in each, each animal
> > supplied with an intravenous line through
> > O which the drug could be injected. The guy in the top chamber
> > received a dose every time he pushed a lever
> > O in his experimental chamber (FR1 schedule) whereas the guy in the
> > bottom chamber was yoked to the one on
> > O top - he received a dose whenever the guy on top did completely
> > independent of his own actions. It turned
> > O out that with this setup, the guy on top was happily pushing the
> > lever and the world seemed perfect
> > O whereas the yoked rat was in a miserable situation unable to cope
> > with this uncontrollable schedule
> > O (mutilating etc). And when they did exactly the same experiment with
> > delivery of sucrose pellets instead
> > O of cocaine both rats were fine. Absolutely mind-blowing !!!
> > OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
> >
> > - Christopher
> >
> > P.S. Does it apply to humans ?



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