cocaine self-administration and yoking

Glen M. Sizemore gmsizemore2 at yahoo.com
Sat Aug 30 08:56:29 EST 2003


C: The effects should be the same as the reinforcement value of the drug
remains constant.

GS: You mean the dose remains the same? Plus, you are not talking about the
reinforcing effects of the drug. The yoked cocaine guys very often die
during such experiments. Why, necessarily, should these effects of the drug
be the same under response-dependent and response-independent conditions?

C: Why is it that denying instrumental control over
delivery of food pellets does not exhibit the effect described whereas
noncontingent injection of cocaine (yoking) does ???

GS: Ummm......because cocaine and food have effects other than their
reinforcing effects.

Your view of dug effects seems to be hopelessly naive. But, then again, your
view is the one encouraged by most pharmacologists, and even some that do
stuff that has come to be called behavioral pharmacology. The fact of the
matter is that there are a host of drug effects that dependent on the
behavioral context. It is nonsense to ask about the effects of drugs without
specifying the context in which the drug is administered.

"Christopher" <papillae at anythingirish.ie> wrote in message
news:410b1d29.0308290209.2e068e1e at posting.google.com...
> > The effects of drugs depend on the behavioral context. A more important
> > question is why you think that the SA rat and the yoked-cocaine rat
would
> > show the same effects.
> The effects should be the same as the reinforcement value of the drug
> remains constant. Why is it that denying instrumental control over
> delivery of food pellets does not exhibit the effect described whereas
> noncontingent injection of cocaine (yoking) does ???
>
> - Christopher
>
> P.S. Btw do rats find injection of sucrose solution rewarding ?





More information about the Neur-sci mailing list