cocaine self-administration and yoking

Glen M. Sizemore gmsizemore2 at yahoo.com
Sat Aug 30 10:17:26 EST 2003


By "yoked control" I meant the yoked cocaine guys, not the yoked saline
rats.

"Glen M. Sizemore" <gmsizemore2 at yahoo.com> wrote in message
news:5354a57200df1cbcf8c4231abadf4e83 at news.teranews.com...
> DA goes up in the Nacc in yoked control rats, but it doesn't go up as much
> as the SA rats.
>
> "BilZ0r" <BilZ0r at TAKETHISOUThotmail.com> wrote in message
> news:Xns93E79E5BC853ABilZ0rhotmailcom at 202.20.93.13...
> > Whats also interesting, is that under these situations, dopamine (DA) is
> > not release in the Nucleus Accumbens (NAc).
> >
> > I was lucky enough to hear a lecture by Prof Michael Joseph from the
> > School of Psychology, University of Leicester, who is an expert on
> > intercranial dialysis recordings of NAc DA activity. He commented on an
> > experiment, where, instead of another rat controlling the dosing regiem,
> > it was a human, and in this experiment, during the first couple random
> > human controlled doses, there was DA release, but then from then on it
> > ceased.
> >
> > papillae at anythingirish.ie (Christopher) wrote in
> > news:410b1d29.0308290209.2e068e1e at posting.google.com:
> >
> > >> The effects of drugs depend on the behavioral context. A more
> > >> important question is why you think that the SA rat and the
> > >> yoked-cocaine rat would show the same effects.
> > > The effects should be the same as the reinforcement value of the drug
> > > remains constant. Why is it that denying instrumental control over
> > > delivery of food pellets does not exhibit the effect described whereas
> > > noncontingent injection of cocaine (yoking) does ???
> > >
> > > - Christopher
> > >
> > > P.S. Btw do rats find injection of sucrose solution rewarding ?
> > >
> >
>
>





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