Neurology 2003 Feb 25;60(4):690-5
Will caloric restriction and folate protect against AD and PD?
Laboratory of Neurosciences, National Institute on Aging, Gerontology
Research Center, Baltimore, MD.
Recent epidemiologic studies of different sample populations have
suggested that the risk of AD and PD may be increased in individuals
with high-calorie diets and in those with increased homocysteine
levels. Dietary restriction and supplementation with folic acid can
reduce neuronal damage and improve behavioral outcome in mouse models
of AD and PD. Animal studies have shown that the beneficial effects of
dietary restriction result, in part, from increased production of
neurotrophic factors and cytoprotective protein chaperones in neurons.
By keeping homocysteine levels low, folic acid can protect cerebral
vessels and can prevent the accumulation of DNA damage in neurons
caused by oxidative stress and facilitated by homocysteine. Although
further studies are required in humans, the emerging data suggest that
high-calorie diets and elevated homocysteine levels may render the
brain vulnerable to neurodegenerative disorders.
PMID: 12601113 [PubMed - in process]
Ongoing CR monkey study update: "In the monkeys...those on
reduced feeding since the study started are dying at a rate
that is about half that of the monkeys receiving a full food
ration." Associated Press: Eating less may extend human life.
August 1, 2002 : http://www.msnbc.com/news/788746.asp?0si=-http://IanGoddard.net/journal.htm
"To lengthen thy life, lessen thy meals." Benjamin Franklin