there is evidence that the protective effect of folate against AD is not
mediated via homocysteine.
[79a] Elevated plasma homocysteine levels in centenarians are not associated
with cognitive impairment. Ravaglia G, Forti P, Maioli F, Vettori C, Grossi
G, Bargossi AM, Caldarera M, Franceschi C, Facchini A, Mariani E, Cavalli G
in Mech Ageing Dev 2000 Dec 20;121(1-3):251-61
"Demented centenarians had the lowest folate serum levels."
[79b] Homocysteine, vitamin B6, and vascular disease in AD patients. Miller
JW, Green R, Mungas DM, Reed BR, Jagust WJ in Neurology 2002 May
"Elevated plasma homocysteine in patients with AD appears related to
vascular disease and not AD pathology. In addition, low vitamin B(6) status
is prevalent in patients with AD."
Michael C Price
"Ian Goddard" <igoddard at erols.mom> wrote in message
news:4n736v0kmmtb0jsphc15tkojf7ofr4lotn at 4ax.com...
> Neurology 2003 Feb 25;60(4):690-5
>> Will caloric restriction and folate protect against AD and PD?
>> Mattson MP.
>> Laboratory of Neurosciences, National Institute on Aging, Gerontology
> Research Center, Baltimore, MD.
>> Recent epidemiologic studies of different sample populations have
> suggested that the risk of AD and PD may be increased in individuals
> with high-calorie diets and in those with increased homocysteine
> levels. Dietary restriction and supplementation with folic acid can
> reduce neuronal damage and improve behavioral outcome in mouse models
> of AD and PD. Animal studies have shown that the beneficial effects of
> dietary restriction result, in part, from increased production of
> neurotrophic factors and cytoprotective protein chaperones in neurons.
> By keeping homocysteine levels low, folic acid can protect cerebral
> vessels and can prevent the accumulation of DNA damage in neurons
> caused by oxidative stress and facilitated by homocysteine. Although
> further studies are required in humans, the emerging data suggest that
> high-calorie diets and elevated homocysteine levels may render the
> brain vulnerable to neurodegenerative disorders.
>> PMID: 12601113 [PubMed - in process]
>> Also SEE:
>http://groups.google.com/groups?selm=3cf51689.125567659%40news.erols.com>> Ongoing CR monkey study update: "In the monkeys...those on
> reduced feeding since the study started are dying at a rate
> that is about half that of the monkeys receiving a full food
> ration." Associated Press: Eating less may extend human life.
> August 1, 2002 : http://www.msnbc.com/news/788746.asp?0si=->>http://IanGoddard.net/journal.htm>> "To lengthen thy life, lessen thy meals." Benjamin Franklin