What happen to normal cells with spontaneous mutations?

Bob xyzbbruner at uclink4.berkeley.edu
Sun Mar 16 12:16:24 EST 2003


On 15 Mar 2003 21:43:36 -0800, chang_edison at hotmail.com (EdiSon)
wrote:

>Spontaneous gene mutations occur in normal cells due to the limited
>accuracy of DNA replications and repairs. Are these normal cells with
>gene mutations then subsequently removed by cell apoptosis?? What
>happen to them? 


There is no general answer. As your suggested solution implies, it
depends on what the effect is. Most such mutations would have no
effect; in fact, most would be in silent regions of the genome. Some
might express the mutations and show some effect; a spot of pigmented
skin might be an example that would be visible. Some might grow "too
much"; if not checked, these mutant cells could turn into cancer.

bob





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