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Opioids and cancer

James Michael Howard jmhoward at arkansas.net
Fri May 2 08:39:08 EST 2003

Again, opiates may be part of normal cell function in more primitive cells.
This was hard to find, but here is an example:

"The potential of embryonic skeletal tissue to synthesize proenkephalin-derived
peptides is retained in the adult in small defined undifferentiated cell
populations. This potential is realized in certain situations requiring rapid
growth, such as remodeling or fracture repair. We suggest that in these
processes, similarly to the situation in the embryo, the undifferentiated
dividing cells produce the endogenous opioids. In the adult these peptides may
have a dual function, namely participating in the control of tissue regeneration
and in the control of pain."  J Cell Biochem 1994 Jul;55(3):334-9

On Fri, 02 May 2003 13:11:46 GMT, "KP-PC" <k.p.collins at worldnet.att.net%remove%>

>"James Michael Howard" <jmhoward at arkansas.net> wrote in message
>news:cup4bv4kp3th060okqoj5ag89ck1n30nsg at 4ax.com...
>| Well, I should have been more specific.  I suggest
>| these receptors are probably more closely associated
>| with cells that are more "embryonic," that is, less
>| differentiated.  Cancer cells are more like this, so
>| receptors of this type may be expressed in them.
>It wasn't only receptors, and it was cancer-specific:
>Quoting from the abstract:
>"Radioimmunoassays revealed the presence of beta-endorphin and
>methionine-enkephalin in these tumors. [...] These results suggest
>that opioid receptors and
>endogenous opioids are fundamental features of human and animal
>The opiates are in-there.
>K. P. Collins

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