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Opioids and cancer

KP-PC k.p.collins at worldnet.att.net%remove%
Fri May 2 13:57:19 EST 2003

Sorry, it fits better with my analysis than it does with the concept
of 'endogenous opioids as growth factors'.

1. Because of the getting-carved-into-'stone-ness in "embryonic
skeletal tissue" there's a genuine need for a 'quieting' of
whatever's in-there in the way of 'pain' detection. "the
undifferentiated dividing cells" is, itself, a relatively-disordered
condition which reflects the gist of the position I've taken.
Relative to the rest of a biological system, localized growth is,
itself an 'irritant' - an energenitically-imbalanced condition -
which is exactly what I was referring to with respect to cancer's
wild growth, only, in the latter, moreso.

2. With respect to "situations requiring rapid growth, such as
remodeling or fracture repair" in adult(? it's not clear from the
abstract), as the abstract hints at, but doesn't seem to make the
connection, otherwise [absent some 'quieting' mechanism], "OUCH!".

3. "proenkephalin-derived peptides" are precursor proteins, not [yet]
bonified 'opiates'.

4. "control of tissue regeneration and in the control of pain" are
'opposing' processes, so, although it's not impossible, it's unlikely
that such processes would be handled by a single macro-molecule
because too much 'intelligence' would, then be built-into the
macro-molecule, which would cause big problems in overall-systematic
control [it's require 'extra layers at the 'level' of the organism -
to interface with what would be an overly-'intelligent'
macro-molecule, and that'd be 'just' entirely Waste, so it's
unlikely - evolutionary dynamics =key= upon zeroing-in on efficiency
with respect to WDB2T.

Conclusion: The stuff of my Prediction has only become stronger in
the light of the abstract you've posted. [Just because this or that
gets Published, and that or this is 'refused' Publication doesn't
make what's Published True and that which is not Published False. It
does, however, 'comment' upon 'the system' :-]

[BTW, in what I've discussed with respect to this thread's focus. I'm
=just= 'skimming-the-surface' of the 'world' of molecular 3-D
energydynamics as they interface with overall 3-D energydynamics. The
discussion 'goes on forever', right into 'atomic' Physics [Tapered
Harmony's realm].]

K. P. Collins

"James Michael Howard" <jmhoward at arkansas.net> wrote in message
news:ops4bvob9255qp65lr9qqj2uh9glt8e5gc at 4ax.com...
| Again, opiates may be part of normal cell function in more
primitive cells.
| This was hard to find, but here is an example:
| "The potential of embryonic skeletal tissue to synthesize
| peptides is retained in the adult in small defined undifferentiated
| populations. This potential is realized in certain situations
requiring rapid
| growth, such as remodeling or fracture repair. We suggest that in
| processes, similarly to the situation in the embryo, the
| dividing cells produce the endogenous opioids. In the adult these
peptides may
| have a dual function, namely participating in the control of tissue
| and in the control of pain."  J Cell Biochem 1994 Jul;55(3):334-9
| On Fri, 02 May 2003 13:11:46 GMT, "KP-PC"
<k.p.collins at worldnet.att.net%remove%>
| wrote:
| >"James Michael Howard" <jmhoward at arkansas.net> wrote in message
| >news:cup4bv4kp3th060okqoj5ag89ck1n30nsg at 4ax.com...
| >| Well, I should have been more specific.  I suggest
| >| these receptors are probably more closely associated
| >| with cells that are more "embryonic," that is, less
| >| differentiated.  Cancer cells are more like this, so
| >| receptors of this type may be expressed in them.
| >[...]
| >
| >It wasn't only receptors, and it was cancer-specific:
| >
| >Quoting from the abstract:
| >
| >"Radioimmunoassays revealed the presence of beta-endorphin and
| >methionine-enkephalin in these tumors. [...] These results suggest
| >that opioid receptors and
| >endogenous opioids are fundamental features of human and animal
| >cancers."
| >
| >The opiates are in-there.
| >
| >K. P. Collins

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