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Antidepressants in childhood: danger???

KP-PC k.p.collins at worldnet.att.net%remove%
Mon May 12 22:02:31 EST 2003


=Jackie Robinson=

Sorry, Mr. Robinson.

K. P. Collins

--
"Schmitd! Schmitd! Ve vill build a Shapel!"

"KP-PC" <k.p.collins at worldnet.att.net%remove%> wrote in message
news:_dZva.81254$cO3.5402731 at bgtnsc04-news.ops.worldnet.att.net...
| Sorry, I wanted to include further discussion, but it slipped by
| because I was 'watching' and Celebrating Jacki Robinson's Triumph
on
| PBS as I was writing my prior reply. "Whoops!" I've added the brief
| discussion below.
|
| --
| "Schmitd! Schmitd! Ve vill build a Shapel!"
|
| "KP-PC" <k.p.collins at worldnet.att.net%remove%> wrote in message
| news:h2Zva.81248$cO3.5400608 at bgtnsc04-news.ops.worldnet.att.net...
| | I've 'read' [incompletely] the article. It;s good in the data it
| | presents, but its synthesis is almost entirely mis-taken.
| |
| | The concept of "circadian pacemaker" is False in its entirety.
| |
| | It's all as I've expained in former posts [not too long ago]. The
| | Determining thing is degree to which nervous-system
| | information-processing capacity is 'used-up' during any waking
| | 'period'.
| |
| | Within such, the various TD E/I-minimization 'zones' each have
| their
| | own 'say' in what will be the net TD E/I-minimization
determination
| | of the "circadian" functionality.
| |
| | It has to be this way because, if 'atypical' experiential
| | circumstances were to be allowed to 'escape' TD E/I-minimization
| | governance, they would induce relative 'randomness' [TD E/I(up)]
| back
| | upon the rest of the "supersystem", which would degrade
| "supersystem'
| | performance, and negatively-impact Survival.
| |
| | The concept of "circadian pacemaker" is False in its entirety.
| |
| | What there is, instead, is globally-integrated TD
E/I-minimization.
| |
| | This said, "of course" the 'normal' '24-hour' day/night cycles
are
| | very-'convenient' with respect to any evolutionarily-'engineered'
| | allotment of nervous-system information-processing capacity
usage.
| | "Of course".
|
| If there was a 'biological clock' then folks who lived in Arctic
and
| Antarctic climes would be totally 'out-to-lunch', wouldn't they?
:-]
| But, instead, they are robustly-adapted to the demands of these
sever
| climates, =be-cause= they are not encumbered by what would be the
| anti-survival dictates of non-existent 'biological clocks'. Forgive
| me, please. It's =hard= to experience my Science's 'being' so
| thoughtlessly wayward.  kpc
|
| | But there exist =no= 'clocks' within nervous systems.
| |
| | There is 'just' awesomely-globally-integrated TD
E/I-minimization,
| | through which external 3-D energydynamics are 'grasped' and
| | transformed into internal 3-D energydynamics.
| |
| | The rigorous maintenance of Topological-order within this 3-D
| | energydynamics 'transformation' is the =single= ''measure' of
| nervous
| | system information-processing functionality.
| |
| | No 'clock' can achieve such Topological-order maintenance,
| therefore,
| | there can be no 'clocks' within nervous systems.
| |
| | Asertions that 'clocks exist' within nervous systems is 'just' a
| | False finitization [AoK, Ap4] that derives in an illusory and
| | unwarranted application of a rather-'ancient' technological 'fad'
| | within non-physically-correlated 'theory'. [See =The
Discoverers+,
| by
| | Daniel Boorstein, for useful background info with respect to the
| way
| | that such "technological fads" spill-over within theoretical
| | efforts.]
| |
| | The concept of 'ciradian pacemaker' is less-than-Worthless,
because
| | it actually blocks understanding of how nervous systems process
| | information.
| |
| | It's just Wrong.
| |
| | K. P. Collins
| |
| | --
| | "Schmitd! Schmitd! Ve vill build a Shapel!"
| | "John H." <johnh at faraway.xxx> wrote in message
| | news:3ebf283b at dnews.tpgi.com.au...
| | | The below suggests to me that the current push to administer
| | antidepressants
| | | to children may predispose to depression in later life. Can
| someone
| | help me
| | | here?
| | |
| | |
| | | John H.
| | |
| | | http://www.niaaa.nih.gov/publications/arh25-2/126-135-text.htm
| | |
| | |
| | | Research from several laboratories has established that
treatment
| | with
| | | antidepressants early in life in otherwise normal rats produces
| | behavioral
| | | and physiological effects in adulthood that resemble human
| | depression. After
| | | neonatal treatment with antidepressants, such as clomipramine
and
| | | desipramine, adult rats show alterations in sleep, sexual
| activity,
| | and
| | | other behaviors that appear to mimic those seen in depressed
| | patients. Of
| | | particular interest here are studies indicating that neonatal
| | antidepressant
| | | treatment increases voluntary alcohol intake and decreases
| activity
| | in the
| | | serotonin neurotransmitter system--findings that are parallel
to
| | | observations in human subjects linking decreases in brain
| serotonin
| | activity
| | | to both depression and alcohol consumption.
| | |
| | | Four separate studies have examined free-running circadian
| rhythms
| | in adult
| | | animals treated with antidepressants in early postnatal life;
two
| | of these
| | | studies used clomipramine-treated hamsters, the third one
studied
| | | clomipramine-treated rats, and the fourth study used
| | desipramine-treated
| | | rats. Although one hamster study failed to detect any
significant
| | effects of
| | | neonatal clomipramine treatment on circadian rhythms (Klemfuss
| and
| | Gillin
| | | 1998), the other reported shortening of the free-running period
| | (under
| | | constant light) and increased circadian amplitude (Yannielli et
| al.
| | 1998).
| | | In rats, the researchers reported lengthening of the
free-running
| | period (in
| | | constant darkness) after neonatal desipramine treatment
| | (Rosenwasser and
| | | Hayes 1994) and increased circadian amplitude and voluntary
| alcohol
| | intake
| | | after both neonatal desipramine and clomipramine treatments
| | (alcohol intake
| | | was not assessed in the hamster experiments) (Dwyer and
| Rosenwasser
| | 1998;
| | | Rosenwasser and Hayes 1994). These studies indicate that
neonatal
| | | antidepressant treatment, like other animal models of
depression,
| | is
| | | associated with alterations in the circadian pacemaker.
| | |
| | |
| | |
| |
| |
|
|





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