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Ephedrine Neurotoxicity

Ian Goddard igoddard at erols.mom
Sat May 24 23:41:22 EST 2003

Toxicology Letters, 2001 Dec 15;125(1-3):151-66: 

"Multiple doses of the dietary supplement L-ephedrine can cause severe
hyperthermia and modest dopamine depletions in the rat brain. ...
Extensive neurodegeneration in the parietal cortex after L-ephedrine
treatment was as pronounced as that previously described for
D-amphetamine treatment ... The results of this study, in conjunction
with human clinical evaluation of ephedrine neurotoxicity, indicate
that regionally specific damage may occur in the cortex of some humans
exposed to ephedrine in the absence of stroke or hemorrhage."

Toxicological Sciences, 2000 May;55(1):133-42:

"l-Ephedrine is an active ingredient in several herbal formulations
... levels of dopamine 7 days after dosing were reduced only 25% or
less by ephedrine compared to the 75% reductions produced by
amphetamine. ... l-Ephedrine may not be as neurotoxic to dopaminergic
terminals as d-amphetamine..." But it's apparently still neurotoxic!

Toxicological Sciences, 2000 Aug;56(2):424-30:

"The objective of this study is to investigate the relative toxicity
of ma-huang extracted under different conditions. ... (1) The
cytotoxicity of all ma-huang extracts could not be totally accounted
for by their ephedrine contents, suggesting the presence of other
toxins in the extracts. ... (3) The relatively high sensitivity of the
Neuro-2a cell line to the toxicity of ma-huang extracts suggests that
the toxic principles were acting on neuronal cells. ..."


  "To lengthen thy life, lessen thy meals." Ben Franklin   

  Ongoing CR monkey study update: "In the monkeys...those on
  reduced feeding since the study started are dying at a rate 
  that is about half that of the monkeys receiving a full food
  ration." Associated Press: Eating less may extend human life.
  August 1, 2002 : http://www.msnbc.com/news/788746.asp?0si=-


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