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CNS Symptoms of a Theoretical Calcium Insufficiency

NMF neil.fournier at sympatico.ca
Sat Oct 4 17:24:19 EST 2003

Quiescence was referring to the complete inactivation of neuronal activity.
Which Never Happens In Normal Conditions.  If a particular neuron that is
generally always tonically-activated displays a reduction in activity due to
particular inhibitory stimulus or via activation of inhibitory interneuronal
populations, then compared to baseline you consider that the neuron has
become "quiet" .   B/c using the term "quiet" is often enormously flawed
from an electrophysiological and semantic perspective it is best to make
sure that when using such terms they are restricted in use (unless of course
you discussing with people who have a familiarity in the field of
neurophysiology who know the term "quiet" or "quiescent" are relative terms
and used for semantic ease in discussion.  It is often annoying when people
begin talking about neuronal activity without ever performing an
extracellular recording or patch-clamp and actually make the measurements to
witness first hand "neuronal communication").    Often relative activity is
based upon a computation from a signal to noise ratio.  There will always be
some level of activation (enormously.e. background noise in which a specific
signal is superimposed).  But please remember most people when they read or
hear  the word, "quiescent", believe that activity of all kinds is
suppressed and that the neuron basically becomes "asleep".  This becomes a
semantic issue.  Unfortunately, words and the choice of words that we use
are not necessarily accurate representations of the phenomena being
measured.  That is why great importance must be given when communicating the
subject matter from any field.    The specific choice of the words used to
explain the phenomena  can evoke different impressions of how the phenomena
(and/or subject) operates in nature.    "Quiescence" can often be construed
to represent complete inactivation or the totality of response.


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