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Could a male fertility pill adversely affect inhibition via allopregnanolone levels?

kofi kofi at anon.un
Wed Oct 8 14:04:17 EST 2003

In article 
<Matthew.Kirkcaldie-D804FD.12433008102003 at seagoon.newcastle.edu.au>,
 Matthew Kirkcaldie <Matthew.Kirkcaldie at deletethis.newcastle.edu.au> 

> Oh - and one other comment - considering that the GABA-A receptor 
> saturates very easily under normal transmission, we tend to assume that 
> allopregnanolone is in use all the time as a kind of "gain control" for 
> tonic inhibition.  So interfering with its synthesis would have much 
> more drastic effects than generating anxiety, if enough synthesis was 
> disrupted.  It can produce seizure as I mentioned in my other post.

If someone with some form of TMJ, attention deficit or glutamate 
excitotoxicity experienced a severe worsening of symptoms when taking a 
5AR inhibitor, would you attribute that then to some neurological 
function performed by 5AR itself?

I have communicated with people who took even low dose finasteride and 
experienced, consistently, very palpable differences in the way they 
felt while drinking.

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