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Synaptic communication and re-uptake / reuptake inhibitors / Adrafinil

1234 123412 at 101.com
Wed Dec 15 07:38:11 EST 2004


Hi all,
I have read some stuff about neurology over the internet. There is one 
thing I don't understand about the synaptic communication:

A neuron releases a neurotransmitter in the synapse to communicate with 
another neuron.  Now the second neuron is stimulated and active until 
the re-uptake clears up the neurotransmitter from there, is this correct?

How much time does it take for the re-uptake mechanism to clear up 
everything? I suppose it should be something in the order of magnitude 
of seconds, otherwise an old idea/reasoning wouldn't go out of our mind 
and we wouldn't be able to think to something else, correct?

In this scenario, what is the purpose of the re-uptake inhibitors? To 
confuse our minds by making the old reasonings last in our mind for 
hours instead of seconds?


Also how could things like Adrafinil (norepinephrine agonist) work? Is 
it stored in vesicules at the end of axons together with the 
norepinephrine and released into the synapses together with it?

Is it subject to the same re-uptake as the norepinephrine or it stays in 
the synaptic cleft for a long time until slowly goes to the plasma? (if 
latter: it would cause roughly the same effect of a reuptake inhibitor, 
right?)



TIA



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