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Synaptic communication and re-uptake / reuptake inhibitors / Adrafinil

INFOHAZARD infohazard at gmail.com
Wed Dec 15 23:01:59 EST 2004


On Wed, 15 Dec 2004 13:38:11 +0100, 1234 <123412 at 101.com> wrote:

>Hi all,
>I have read some stuff about neurology over the internet. There is one 
>thing I don't understand about the synaptic communication:
>
>A neuron releases a neurotransmitter in the synapse to communicate with 
>another neuron.  Now the second neuron is stimulated and active until 
>the re-uptake clears up the neurotransmitter from there, is this correct?
>
Complicated...
After an action potential (post synaptic) , there is a refractory
period.  However,  if the NT is in the cleft,  it'll keep stimulating
the receptors.

>much time does it take for the re-uptake mechanism to clear up 
>everything? I suppose it should be something in the order of magnitude 
>of seconds, otherwise an old idea/reasoning wouldn't go out of our mind 
>and we wouldn't be able to think to something else, correct?
>
Sorry,  don't know.

>In this scenario, what is the purpose of the re-uptake inhibitors? To 
>confuse our minds by making the old reasonings last in our mind for 
>hours instead of seconds?
Not reasonings. Brightness,  focus,  contrast, moods.

>
>
>Also how could things like Adrafinil (norepinephrine agonist) work? Is 
>it stored in vesicules at the end of axons together with the 
>norepinephrine and released into the synapses together with it?
>
NE agonist,  eh?  That would be different than modafinil, then....

Not stored.  Diffusion.  Diffusion. OK?


>Is it subject to the same re-uptake as the norepinephrine or it stays in 
>the synaptic cleft for a long time until slowly goes to the plasma? (if 
>latter: it would cause roughly the same effect of a reuptake inhibitor, 
>right?)

The latter.
>
>
>
>TIA

There ought to be one day-- just one-- when 
there is open season on senators.
   -Will Rogers



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